Dr. Frankenstein (Colin Clive) and his monster (Boris Karloff) both turn out to be alive, not killed as previously believed. As the new story begins, Dr. Frankenstein wishes to abandon his evil ways and settle into a peaceful life with his new bride, Elizabeth (Valerie Hobson). But when the sinister Dr. Pretorius (Ernest Thesiger) appears unexpectedly and kidnaps Elizabeth, Dr. Frankenstein agrees to help him create a new creature, a woman (Elsa Lanchester), to be the companion of the monster.