The film tells two stories, taking place in 1909 and 1940, both starring Karamakate (played as a young man by Nilbio Torres and as an older man by Antonio Bolivar) an Amazonian shaman and last survivor of his tribe. He travels with two scientists, German Theodor Koch-Grunberg (Jan Bijvoet) and American Richard Evans Schultes (Brionne Davis), to look for the rare yakruna, a sacred plant. The film is loosely inspired by the diaries written by the two scientists during their field work in the Amazon. Embrace of the Serpent won the Art Cinema Award in the Directors' Fortnight section at the 2015 Cannes Film Festival, and it was nominated for the Best Foreign Language Film at the 88th Academy Awards.